Metabolic traits ruling the specificity of the immune response in different cancer types

Cancer immunotherapy aims to augment the response of patient’s own immune system against cancer cells. Despite effective for some patients and types, therapeutic efficacy this treatment is limited by composition tumor microenvironment (TME), which not well-suited fitness anti-tumoral However, TME differs between types tissues, thus complicating possibility development therapies that would be in a large range patients. A possible scenario each type cell, granted its mutations reminiscent functions tissue origin, has specific metabolism will impinge on metabolic TME, turn specifically affects T cell fitness. Therefore, targeting or could increase specificity existing immunotherapies, improving disease outcome minimizing adverse reactions.